Nucleofill Polynucleotide Treatment in Bristol
Advanced Doctor-Led Skin Regeneration for
Eyes, Face, Neck, Décolletage, Hands & Stretch Marks
Nucleofill Polynucleotide treatment is one of the most advanced regenerative skin therapies available in modern aesthetics. Rather than adding volume or simply hydrating the skin, Nucleofill stimulates your skin to repair, regenerate and rebuild itself, creating results that look natural, healthy and beautifully refreshed.
At Doctor Brad’s Clinic in Bristol, all polynucleotide treatments are delivered exclusively by a medical doctor with extensive expertise in periocular rejuvenation and advanced laser resurfacing. This ensures safe, precise, and effective treatment across even the most delicate and challenging areas of the face and body.
If you want brighter under-eyes, smoother skin, improved texture, healthier collagen, or a more natural alternative to fillers, Nucleofill is a powerful option with consistently high patient satisfaction.
What Is Nucleofill?
Nucleofill is a premium polynucleotide system designed to improve:
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Skin quality and resilience
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Brightness and complexion
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Fine lines and crepiness
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Elasticity and firmness
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Hydration and smoothness
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Overall skin health at a cellular level
Unlike fillers or basic skin boosters, Nucleofill stimulates your skin to:
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Build stronger collagen and elastin
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Improve circulation
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Support lymphatic drainage
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Reduce inflammation
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Enhance natural regeneration
The effect is fresher, healthier, more radiant skin — with results that develop gradually and look beautifully natural.
Why Choose Polynucleotides?
Nucleofill is ideal for people who want:
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A natural, elegant rejuvenation
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Improvement in under-eye skin quality
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Smoother, firmer facial or neck skin
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Enhanced radiance and hydration
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Better results after laser resurfacing
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A safer alternative to tear trough filler
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Gentle but powerful rejuvenation for crepey or delicate areas
Patients love Nucleofill because the improvements come from their own skin’s renewal process, creating subtle but meaningful changes.
Areas That Can Be Treated
Nucleofill can rejuvenate multiple areas, including:
Under Eyes / Tear Trough Skin
Softens crepiness, brightens the area, and improves fine lines.
Face
Enhances texture, glow and firmness for a fresher look.
Neck
Reduces crepiness and softens early signs of ageing.
Décolletage
Improves thin, sun-damaged or uneven chest skin.
Hands
Smooths and revitalises ageing or dehydrated hands.
Stretch Marks
Improves texture, colour and overall quality in targeted areas.
What Results Can You Expect?
Most patients notice:
Early improvements
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Smoother, softer skin
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Better hydration
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Brighter appearance
Progressive improvements
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Firmer, more elastic skin
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Reduced crepiness
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Healthier-looking under-eyes
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Enhanced luminosity
Peak results
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Optimal collagen improvement
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Refined texture
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Natural rejuvenation without looking “done”
Results typically build over several weeks and can last 6–12 months depending on the area treated.
Treatment Experience
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Doctor-delivered treatment only
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Gentle, precise micro-injections
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Usually completed within 15–20 minutes
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Minimal downtime
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Small bumps or mild redness may occur for 24–48 hours
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Most patients return to normal activity immediately
A course of 2–4 sessions, spaced a few weeks apart, is recommended for best results.
Aftercare
CLICK HERE for our polynucleotide treatment aftercare advice.
Nucleofill vs Tear Trough Filler
Nucleofill is a popular option for patients who prefer a safer and more natural approach to under-eye rejuvenation.
Compared with filler, polynucleotides:
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Improve skin quality instead of volume
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Brighten and strengthen delicate under-eye skin
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Avoid risks of puffiness, migration or heaviness
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Create subtle, natural-looking results
For suitable candidates, Nucleofill offers an elegant alternative to traditional tear trough filler.
Who Performs the Treatment?
All Polynucleotide treatments at the clinic are performed exclusively by Dr Brad, a medical doctor with extensive experience in periocular treatments, facial regeneration and CO₂ laser resurfacing.
You’ll receive clear guidance, honest expectations and a highly personalised treatment plan.
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Pricing
Nucleofill Polynucleotide Treatments
Eyes / Tear Trough Skin Quality
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£375 per session
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Course of 3: £1,050
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Additional syringe (if required): £200
Face (cheeks, forehead perioral or similar)
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£375 per session
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Course of 3: £1,050
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Additional syringe: £175
Neck
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£375 per session
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Course of 3: £1,050
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Additional syringe: £175
Décolletage
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£375 (standard area, one syringe)
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£550 (larger area requiring two syringes)
Hands
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£375 per session
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£550 if a second syringe is required
Stretch Marks (REVIDA Reclaim + PN)
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Small area: £375
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Medium area: £375 + £175 supplement
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Large area: £550–£725 depending on syringe requirement
PN Add-On for CO₂ Laser (Revida Protocols)
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£330 per area
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Additional syringe supplements within the same area apply at £175 as required
PN Add-On for QUEST³ Laser Facial within the same session.
Recommended from session 2 onwards of the QUEST³ program.
Improves dermal hydration, elasticity and fine lines. Ideal for eyelids, tear troughs, cheeks, neck or hands.
Pay just £725 for the QUEST³ laser facial plus one facial area PN treatment same day (£175 for any additional facial syringes requested in the same session). Facial areas are one of : both cheeks, forehead, perioral area, for example.
FAQs
How many treatments will I need?
Most people benefit from 2–4 sessions. Your plan will be tailored to your goals and skin quality.
How long does it last?
Results typically last 6–12 months.
Is there downtime?
Only minimal downtime — most patients resume normal activity immediately.
Does the treatment look natural?
Yes. Nucleofill creates subtle, refined improvements by supporting your skin’s own regenerative pathways.
Can I have Nucleofill if I’ve had fillers before?
Yes — it is often ideal for improving the quality of skin overlying previous filler treatment.
Book Your Consultation
If you are considering Nucleofill to brighten your under eyes, rejuvenate your skin or support long-term collagen health, you’re welcome to book a consultation.
Together we’ll build a tailored plan based on your goals, anatomy and skin quality.